The "harlequin" pattern in rabbits, as shown by Wasabi here (submitted by Beth), can look similar to brindle in dogs. See the E series page for more information on grizzles and how Eg interacts with brindle. Brindle with a Mask Silver brindle is often caused by the greying gene (G locus), which turns black to grey as the dog ages. Links to studies: ** Please note that I am not a research scientist, and the information on this page comes from my own knowledge and observation of dogs, observational and testing data provided via e-mail by site visitors, any research papers linked on the page, and the information provided by Dr Sheila M. Schmutz on her excellent website http://homepage.usask.ca/~schmutz/dogcolors.html It is possible that the Eh allele (which causes a similar pattern in Cocker Spaniels) and the Ed allele (Northern domino, in Husky types) interact with brindle in a similar way too. No time to read the whole thing? Because a brindle dog will have some cells expressing ky and some expressing KB, this makes testing for brindle extremely difficult. Apart from horses and dogs, one of the only other species that appears to have a similar brindle pattern is domestic cattle, like the bull above. Liver and brindle do not occur together on many breeds, however the combination is fairly common in Pit Bull types. Interestingly, a form of mosaicism in humans results in a brindle-like pattern known as Blaschko lines. Are you looking to figure out what breed your new furry friend is? Even between longhaired breeds, the visibility of brindle can vary. Because a brindle dog will have some cells expressing ky and some expressing KB, this makes testing for brindle extremely difficult. The thickness of the stripes can vary, so the dog may look predominantly dark or predominantly red. The dark (eumelanin) stripes on a brindle can be affected by liver, dilution, greying or merle, and the light/red (phaeomelanin) stripes can be affected by the Intensity locus. Dogs with the Eg (grizzle/domino) allele seem to show brindle mostly on their darker areas or saddles, as the Saluki puppy above shows. appear solid brindle (in fact, all solid brindles are sables), although any areas of shading will remain dark. Dogs with the Eg gene (Salukis, Borzoi, Afghan Hounds) are affected differently by brindle, with the brindling appearing mostly on the dark (eumelanin) areas of the dog. can see a large clear area on the dog's side. Here are three blue brindles. appear solid brindle (in fact, all solid brindles are sables), although any areas of shading will remain dark. and on the chest and legs is almost white. When the liver and dilution genes are combined, the result is isabella (lilac). ** Please note that I am not a research scientist, and the information on this page comes from my own knowledge and observation of dogs, observational and testing data provided via e-mail by site visitors, any research papers linked on the page, and the information provided by Dr Sheila M. Schmutz on her excellent website http://homepage.usask.ca/~schmutz/dogcolors.html A brindle dog will have liver (brown) stripes if it is bb on the B locus, blue stripes if it is dd on the D locus, Dogs with the Eg gene (Salukis, Borzoi, Afghan Hounds) are affected differently by brindle, with the brindling appearing mostly on the dark (eumelanin) areas of the dog. Because a brindle dog will have some cells expressing ky and some expressing KB, this makes testing for brindle extremely difficult. The brindling is still present as normal at skin level, but becomes obscured by long coats. but the genetic basis is unknown. and isabella stripes if it is both dd and bb. The main patterns The gene causing brindle in cattle has not yet been located, but as it is common and inherited it can't be caused by chimaerism, as in horses, and cattle are not known to have any BD103 colour genes, so the mechanism must be different to brindle in dogs. is a brindle. The Whippet is a very light brindle, and the blue colouration is mostly visible on the mask and nose. Here's the quick version! Dilution affects phaeomelanin (red) too to some extent, so the base colour These dogs look very similar to a saddle tan or shaded sable, but the pattern is caused by a different mechanism. There is only a very small bit of tan visible on the hip, and the rest of the dog appears solid black. 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